What is Nodding Syndrome and how do you investigate if you come across a case series?

In this installment of the CDC MMWR, epidemiologists from CDC describe a great investigation of a cluster of disease known as Nodding Syndrome they received reports of, from South Sudan. The story of their tracking it (using case series and case control studies to get to the heart of it) is very instructive. Nodding syndrome is repetitive nodding of head along with signs of seizure prevalent in parts of Africa. It appears that infection with Oncerca volvulus may play a role in it, but the story of their investigation into the cause of the disease makes for interesting reading.


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